About Immunity in A Level Biology
Immunity is one of the 11 main topics in our A Level Biology (Cambridge (CAIE) 9700) question bank, and about 5% of its real questions come from it. Tayyari Karo has 30 real questions on this topic from 2021 to 2026, from Paper 1, Paper 2; 26 are multiple choice and marked instantly, and the rest are structured questions with a model answer. By difficulty: 22 medium, 4 hard, 4 easy.
Work through the questions below, then open the explanation for each one. Redo the ones you missed a few days later.
Try 6 real questions
These are real past-paper questions. Think of your answer first, then open the explanation.
May/June 2026 · Paper 1 · Immunity
Which type of cell is fused with a myeloma cell in monoclonal antibody production?
- B-lymphocyte
- hybridoma
- T-lymphocyte
- stem cell
Show answer and explanation
Answer: A. B-lymphocyte
Antibody-producing B-lymphocytes are fused with myeloma cells to form hybridomas.
October/November 2025 · Paper 1 · Immunity
The hybridoma method is used for the production of monoclonal antibodies. Which two types of cell are used in this method?
- stem cell and B-lymphocyte
- stem cell and T-lymphocyte
- tumour cell and B-lymphocyte
- tumour cell and T-lymphocyte
Show answer and explanation
Answer: C. tumour cell and B-lymphocyte
A hybridoma is formed by fusing an antibody-producing B-lymphocyte (plasma cell) with a tumour (myeloma) cell to give a cell that divides indefinitely and secretes a single antibody.
October/November 2024 · Paper 1 · Immunity
What will be produced by the division of memory cells during a secondary immune response?
- macrophages
- plasma cells
- neutrophils
- monocytes
Show answer and explanation
Answer: B. plasma cells
Memory B cells divide rapidly during a secondary immune response to form plasma cells, which secrete large quantities of antibody.
May/June 2023 · Paper 1 · Immunity
Repeated infections with malaria result in more effective immunity to malaria. Which type of immunity is responsible for the more effective immunity?
- artificial active
- artificial passive
- natural active
- natural passive
Show answer and explanation
Answer: C. natural active
Repeated natural infection stimulates the person's own immune system to produce memory cells and antibodies, giving natural active immunity.
May/June 2022 · Paper 1 · Immunity
Which types of cell are stimulated to divide by the cytokines produced by T-helper cells?
- macrophages
- B-lymphocytes only
- T-killer cells only
- B-lymphocytes and T-killer cells
Show answer and explanation
Answer: D. B-lymphocytes and T-killer cells
Cytokines released by T-helper cells stimulate clonal expansion (division) of both B-lymphocytes and T-killer cells as part of the specific immune response.
May/June 2021 · Paper 1 · Immunity
What are functions of T-lymphocytes?
1 production of cytokines
2 production of toxins
3 recognition of an antigen bound to an antigen-presenting cell
- 1, 2 and 3
- 1 and 2 only
- 1 and 3 only
- 2 and 3 only
Show answer and explanation
Answer: C. 1 and 3 only
T-lymphocytes produce cytokines and recognise antigen presented on antigen-presenting cells; production of toxins is not a function of T-lymphocytes, so only 1 and 3 are correct.