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A Level Biology: Immunity, questions with answers

Practise 30 real questions on Immunity from 2021 to 2026. See the answer and explanation as soon as you answer.

30real questions
26multiple choice
11exam sessions

About Immunity in A Level Biology

Immunity is one of the 11 main topics in our A Level Biology (Cambridge (CAIE) 9700) question bank, and about 5% of its real questions come from it. Tayyari Karo has 30 real questions on this topic from 2021 to 2026, from Paper 1, Paper 2; 26 are multiple choice and marked instantly, and the rest are structured questions with a model answer. By difficulty: 22 medium, 4 hard, 4 easy.

Work through the questions below, then open the explanation for each one. Redo the ones you missed a few days later.

Try 6 real questions

These are real past-paper questions. Think of your answer first, then open the explanation.

May/June 2026 · Paper 1 · Immunity

Which type of cell is fused with a myeloma cell in monoclonal antibody production?

  1. B-lymphocyte
  2. hybridoma
  3. T-lymphocyte
  4. stem cell
Show answer and explanation

Answer: A. B-lymphocyte

Antibody-producing B-lymphocytes are fused with myeloma cells to form hybridomas.

October/November 2025 · Paper 1 · Immunity

The hybridoma method is used for the production of monoclonal antibodies. Which two types of cell are used in this method?

  1. stem cell and B-lymphocyte
  2. stem cell and T-lymphocyte
  3. tumour cell and B-lymphocyte
  4. tumour cell and T-lymphocyte
Show answer and explanation

Answer: C. tumour cell and B-lymphocyte

A hybridoma is formed by fusing an antibody-producing B-lymphocyte (plasma cell) with a tumour (myeloma) cell to give a cell that divides indefinitely and secretes a single antibody.

October/November 2024 · Paper 1 · Immunity

What will be produced by the division of memory cells during a secondary immune response?

  1. macrophages
  2. plasma cells
  3. neutrophils
  4. monocytes
Show answer and explanation

Answer: B. plasma cells

Memory B cells divide rapidly during a secondary immune response to form plasma cells, which secrete large quantities of antibody.

May/June 2023 · Paper 1 · Immunity

Repeated infections with malaria result in more effective immunity to malaria. Which type of immunity is responsible for the more effective immunity?

  1. artificial active
  2. artificial passive
  3. natural active
  4. natural passive
Show answer and explanation

Answer: C. natural active

Repeated natural infection stimulates the person's own immune system to produce memory cells and antibodies, giving natural active immunity.

May/June 2022 · Paper 1 · Immunity

Which types of cell are stimulated to divide by the cytokines produced by T-helper cells?

  1. macrophages
  2. B-lymphocytes only
  3. T-killer cells only
  4. B-lymphocytes and T-killer cells
Show answer and explanation

Answer: D. B-lymphocytes and T-killer cells

Cytokines released by T-helper cells stimulate clonal expansion (division) of both B-lymphocytes and T-killer cells as part of the specific immune response.

May/June 2021 · Paper 1 · Immunity

What are functions of T-lymphocytes?
1 production of cytokines
2 production of toxins
3 recognition of an antigen bound to an antigen-presenting cell

  1. 1, 2 and 3
  2. 1 and 2 only
  3. 1 and 3 only
  4. 2 and 3 only
Show answer and explanation

Answer: C. 1 and 3 only

T-lymphocytes produce cytokines and recognise antigen presented on antigen-presenting cells; production of toxins is not a function of T-lymphocytes, so only 1 and 3 are correct.

Sessions with Immunity questions

SessionPaper 1Paper 2
May/June 202621
May/June 20251–
October/November 20252–
May/June 202431
October/November 20242–
May/June 20232–
October/November 20233–
May/June 202231
October/November 202221
May/June 20213–
October/November 20213–

Common questions

What does the Immunity topic cover on this page?

30 real A Level Biology (9700) questions on Immunity from 2021 to 2026, from Paper 1, Paper 2. Each one shows the year, session and paper it came from.

Do I get the answers and explanations?

Yes. Every question shows the correct answer and a short explanation the moment you answer.

Is it free?

You can start free with no signup. A small set of papers per subject is free, and Premium unlocks every paper, the full question bank and the paper PDFs.

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