About Disease, immunity and biotechnology in O Level Biology
Disease, immunity and biotechnology is one of the 13 main topics in our O Level Biology (Cambridge (CAIE) 5090) question bank, and about 10% of its real questions come from it. Tayyari Karo has 58 real questions on this topic from 2021 to 2026, from Paper 1, Paper 2, Paper 3, Paper 4; 47 are multiple choice and marked instantly, and the rest are structured questions with a model answer. By difficulty: 49 medium, 6 easy, 3 hard.
Work through the questions below, then open the explanation for each one. Redo the ones you missed a few days later.
Try 7 real questions
These are real past-paper questions. Think of your answer first, then open the explanation.
May/June 2026 · Paper 1 · Disease, immunity and biotechnology
Cholera is caused by a toxin produced by a bacterium. What are the effects of this toxin? 1 Person becomes dehydrated. 2 Ions are secreted into the small intestine. 3 Water moves into the intestine by osmosis.
- 1, 2 and 3
- 1 and 2 only
- 1 and 3 only
- 2 and 3 only
Show answer and explanation
Answer: A. 1, 2 and 3
The toxin makes ions enter the intestine, water follows by osmosis, and the person becomes dehydrated.
Oct/Nov 2025 · Paper 1 · Disease, immunity and biotechnology
Which nutrient deficiency causes scurvy?
- calcium
- iron
- vitamin C
- vitamin D
Show answer and explanation
Answer: C. vitamin C
Oct/Nov 2024 · Paper 1 · Disease, immunity and biotechnology
The spread of HIV was reduced in many countries between 1990 and 2010. Which action assisted this reduction?
- development of an effective vaccine
- health education
- treating patients with new antibiotics
- using drugs that slow the appearance of symptoms of HIV
Show answer and explanation
Answer: B. health education
Oct/Nov 2023 · Paper 1 · Disease, immunity and biotechnology
A car driven at 110 km/h by a driver who has not consumed alcohol travels a certain distance before stopping. If the driver consumes alcohol, the distance travelled before reacting increases by 20%. What is the total distance travelled before stopping?
- 96 m
- 100 m
- 111.2 m
- 115.2 m
Show answer and explanation
Answer: B. 100 m
Oct/Nov 2022 · Paper 1 · Disease, immunity and biotechnology
A patient shows unexplained weight loss, severe thirst and frequent urination; tests show high glucose in urine. Which condition is diagnosed?
- cardiovascular disease
- diabetes
- anaemia
- obesity
Show answer and explanation
Answer: B. diabetes
May/June 2021 · Paper 1 · Disease, immunity and biotechnology
What are the roles of the female mosquito and the malarial pathogen in the spread of malaria?
- parasite / vector
- parasite / parasite
- vector / parasite
- vector / vector
Show answer and explanation
Answer: C. vector / parasite
Oct/Nov 2024 · Paper 2 · Disease, immunity and biotechnology
7 (a) Explain how long-term active immunity develops in the human body after infection by a pathogen. [7]
(b) In any group of humans, there is variation in how well each person's immune system responds to infections. Suggest factors which may contribute to this variation. [3]
Show model answer
(a) The pathogen carries antigens on its surface which the body recognises as foreign; lymphocytes with the complementary antibody are stimulated to divide by mitosis and form a clone; these lymphocytes secrete large numbers of antibodies; each antibody has a shape complementary to the antigen and locks on to it; the antibodies make the pathogens clump together, mark them so that phagocytes engulf them, or neutralise their toxins; after the infection some of these lymphocytes remain as memory cells; if the same pathogen enters again the memory cells produce antibodies much more quickly and in much greater quantity, so the pathogen is destroyed before symptoms appear; the immunity is describe …
The full model answer is in the app.