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O Level Biology: Disease, immunity and biotechnology, questions with answers

Practise 58 real questions on Disease, immunity and biotechnology from 2021 to 2026. See the answer and explanation as soon as you answer.

58real questions
47multiple choice
11exam sessions

About Disease, immunity and biotechnology in O Level Biology

Disease, immunity and biotechnology is one of the 13 main topics in our O Level Biology (Cambridge (CAIE) 5090) question bank, and about 10% of its real questions come from it. Tayyari Karo has 58 real questions on this topic from 2021 to 2026, from Paper 1, Paper 2, Paper 3, Paper 4; 47 are multiple choice and marked instantly, and the rest are structured questions with a model answer. By difficulty: 49 medium, 6 easy, 3 hard.

Work through the questions below, then open the explanation for each one. Redo the ones you missed a few days later.

Try 7 real questions

These are real past-paper questions. Think of your answer first, then open the explanation.

May/June 2026 · Paper 1 · Disease, immunity and biotechnology

Cholera is caused by a toxin produced by a bacterium. What are the effects of this toxin? 1 Person becomes dehydrated. 2 Ions are secreted into the small intestine. 3 Water moves into the intestine by osmosis.

  1. 1, 2 and 3
  2. 1 and 2 only
  3. 1 and 3 only
  4. 2 and 3 only
Show answer and explanation

Answer: A. 1, 2 and 3

The toxin makes ions enter the intestine, water follows by osmosis, and the person becomes dehydrated.

Oct/Nov 2025 · Paper 1 · Disease, immunity and biotechnology

Which nutrient deficiency causes scurvy?

  1. calcium
  2. iron
  3. vitamin C
  4. vitamin D
Show answer and explanation

Answer: C. vitamin C

Oct/Nov 2024 · Paper 1 · Disease, immunity and biotechnology

The spread of HIV was reduced in many countries between 1990 and 2010. Which action assisted this reduction?

  1. development of an effective vaccine
  2. health education
  3. treating patients with new antibiotics
  4. using drugs that slow the appearance of symptoms of HIV
Show answer and explanation

Answer: B. health education

Oct/Nov 2023 · Paper 1 · Disease, immunity and biotechnology

A car driven at 110 km/h by a driver who has not consumed alcohol travels a certain distance before stopping. If the driver consumes alcohol, the distance travelled before reacting increases by 20%. What is the total distance travelled before stopping?

  1. 96 m
  2. 100 m
  3. 111.2 m
  4. 115.2 m
Show answer and explanation

Answer: B. 100 m

Oct/Nov 2022 · Paper 1 · Disease, immunity and biotechnology

A patient shows unexplained weight loss, severe thirst and frequent urination; tests show high glucose in urine. Which condition is diagnosed?

  1. cardiovascular disease
  2. diabetes
  3. anaemia
  4. obesity
Show answer and explanation

Answer: B. diabetes

May/June 2021 · Paper 1 · Disease, immunity and biotechnology

What are the roles of the female mosquito and the malarial pathogen in the spread of malaria?

  1. parasite / vector
  2. parasite / parasite
  3. vector / parasite
  4. vector / vector
Show answer and explanation

Answer: C. vector / parasite

Oct/Nov 2024 · Paper 2 · Disease, immunity and biotechnology

7 (a) Explain how long-term active immunity develops in the human body after infection by a pathogen. [7]
(b) In any group of humans, there is variation in how well each person's immune system responds to infections. Suggest factors which may contribute to this variation. [3]

Show model answer

(a) The pathogen carries antigens on its surface which the body recognises as foreign; lymphocytes with the complementary antibody are stimulated to divide by mitosis and form a clone; these lymphocytes secrete large numbers of antibodies; each antibody has a shape complementary to the antigen and locks on to it; the antibodies make the pathogens clump together, mark them so that phagocytes engulf them, or neutralise their toxins; after the infection some of these lymphocytes remain as memory cells; if the same pathogen enters again the memory cells produce antibodies much more quickly and in much greater quantity, so the pathogen is destroyed before symptoms appear; the immunity is describe …

The full model answer is in the app.

Sessions with Disease, immunity and biotechnology questions

SessionPaper 1Paper 2Paper 3Paper 4
May/June 202652––
May/June 202532––
Oct/Nov 202551––
May/June 2024–1––
Oct/Nov 202451––
May/June 20231–––
Oct/Nov 20236–11
May/June 202261––
Oct/Nov 20226–––
May/June 202161––
Oct/Nov 20214–––

Common questions

What does the Disease, immunity and biotechnology topic cover on this page?

58 real O Level Biology (5090) questions on Disease, immunity and biotechnology from 2021 to 2026, from Paper 1, Paper 2, Paper 3, Paper 4. Each one shows the year, session and paper it came from.

Do I get the answers and explanations?

Yes. Every question shows the correct answer and a short explanation the moment you answer.

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You can start free with no signup. A small set of papers per subject is free, and Premium unlocks every paper, the full question bank and the paper PDFs.

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